Immunity and Blood Type

This is the fourth in a blog series based on information from the book Live Right 4 Your Type by Dr. Peter J. D’Adamo. Previously, I have written about how blood type is associated with:
the mind-body connection,
and metabolism.
I invite you to use these links to read these prior posts before continuing with this one (not necessary, but helpful).
Credit for the image attached this post goes to Dr. Peter J. D’Adamo.


Most people don’t associate blood type with the immune system. The truth is that the immune function of each blood type is probably its most important function, allowing preservation of humans against “friends” and “foes” in the form of viruses, bacteria, cancers, and more. Each blood type possesses a different antigen with its own special chemical structure (see the image included with the Digestion and Blood Type post linked above):

    • The Blood Type O antigen sees O as “self” and all other types as “other” (sees most others as foes). The fucose sugar serves as the basis of the sugars of the other blood types.
    • The Blood Type A antigen is formed by adding a second sugar, N-acetyl-galactosamine, to fucose.
    • The Blood Type B antigen is formed by adding a second sugar, D- galactose, to fucose.
    • Blood Type AB is formed by adding BOTH sugars – N-acetyl-galactosamine AND D-galactose – to fucose. This means that this blood possesses both A and B antigens (sees everything as friendly).

We are genetically programmed to produce incredibly powerful antibodies to opposing blood types (or, most commonly, to microorganisms and foods that have antigens similar to the other blood types). We are not born with antibodies, but – within two weeks of birth – most infants are already becoming sensitized to opposing blood type antigens in their environments, primarily through daily “innoculations” of food. Antibody levels are believed to reach peak levels between ages 3 and 10 and then to start declining. You can see that it is important to “teach” your body with the most appropriate foods to encourage your body to produce antibodies on its own without external interventions whenever possible. For example, the increased use of preventive vaccinations – rather than relying on appropriate foods and other natural therapies –  in recent decades is thought to be a possible cause of increased immune reactivity (excessive agglutination/clumping of red blood cells when exposed to another blood type) in children.

IMMUNOGLOBULIN ANTIBODIES (see image linked to this post)

You will see references to IgA and IgE antibody levels in this post. IgA antibodies are typically found in areas of the body such as the digestive tract, ears, eyes, breathing passages, saliva, tears and blood.  In most people, IgA antibodies account for about 10-15% of total antibodies.  IgE normally represents the lowest concentration of all antibodies, especially in people without allergies. IgE antibodies are found in the lungs, the mucous membranes and the skin. IgE antibodies react to pet dander, pollen, fungus, spores, milk, medicines and some poisons.

For more information on the relationship between IgA levels and allergies/asthma (does not include blood type), see:

For more information on the relationship between IgE levels and allergies/asthma (does not include blood type), see:


In general, non-secretors are far more likely to suffer from an immune-related disease than secretors, especially when the disease is provoked by an infectious organism. Non-secretors are more likely to view their own tissue as unfriendly.

Non-secretors are dominant in virtually every immune system disorder:

    • Non-secretors are more prone to generalized inflammation than secretors
    • Non-secretors are more prone to developing both type 1 and type 2 diabetes than secretors
    • Non-secretors who have type 1 diabetes have much more consistent problems with the yeast Candida albicans, especially in their mouths and upper gastrointestinal (GI) tracts
    • Non-secretors account for 80% of all fibromyalgia sufferers across all blood types
    • Non-secretors have an increased prevalence of a variety of autoimmune diseases including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, Sjogren’s syndrome, multiple sclerosis (MS), and Grave’s disease
    • Non-secretors have an extra risk of recurrent urinary tract infections, and between 55-60% of non-secretors have been found to develop renal scarring even with the regular use of antibiotic treatment for UTIs
    • Non-secretors comprise 20% of the population but present 80% of the cases that doctors categorize as “complex”. They are hard to diagnose, and they heal much more slowly than their secretor counterparts.



Individuals with blood type O manufacture high levels of antigens that act against blood types A and B. The Type O antigen is fucose sugar. Type Os have high antibody IgA (Immunoglobulin A) and IgE (Immunoglobulin E) levels.


Increased Risks

    • Inflammatory bowel disease and other inflammatory conditions
    • Ulcers
    • Respiratory allergies
    • Autoimmune disease, especially of the thyroid
    • Denture inflammation and plaque


    • Non-Secretors
      • Risk of autoimmune disease and inflammatory bowel disease is even higher than in O secretors
      • More prone to generalized inflammation
      • Greater risk of respiratory problems, especially allergies
      • Lower risk of elevated IgA levels, but increased risk of dental problems


Individuals with blood type A manufacture low levels of IgA and IgE antibodies. Tumor markers resemble Type A antigens.


    • Low IgA levels create vulnerability to ear and respiratory infections and create susceptibility to gastrointestinal (GI) infections
    • Low IgE levels promote allergies and asthma
    • Because tumor markers resemble Type A antigens:
      • Individuals with Type A blood have weakened Natural Killer (NK) cell activity. NK cells provide rapid responses to virus-infected cells, acting at around 3 days after infection, and respond to tumor formation.
      • The immune system’s ability to discriminate between friend and foe is impaired.


    • Celiac disease
    • Rheumatic heart disease
    • Kidney disease
    • Most cancers


    • Non-Secretors
      • Low IgA levels result in higher risk of ear and respiratory infections and susceptibility to GI infections. Non-secretor children in particular have a greater incidence of ear infections.


Individuals with blood type B are significantly impacted by the fact that many bacteria have B-like antigens. Bs are particularly susceptible to slow-growing viral infections.


    • B antigens don’t mount attacks against infections with bacterial antigens that resemble their own
    • Dysfunctional immune reactions don’t stop slow-growing viral infections

Increased Risks

    • Influenza (severe)
    • E coli infection (severe when contracted)
    • Gastroenteritis
    • Urinary tract infections (UTIs)
    • Staph infections
    • Sinus infections
    • Autoimmune disease
    • Type 1 diabetes


    • Children
      • Risk of neonatal strep infection, especially if the mother is Type B
    • Ancestry
      • Asians have special risk of tuberculosis (TB)
      • Type B African-Americans have special risk of type 1 diabetes and autoimmune disease
    • Non-secretors
      • Type B non-secretors have the highest rate of UTIs of all blood types


Individuals with blood type AB have low antibody IgA and IgE levels. They also lack anti-A and anti-B immune response capabilities.


    • Low IgA levels create vulnerability to ear and respiratory infections and create susceptibility to gastrointestinal (GI) infections
    • Low IgE levels promote allergies and asthma
    • Absence of anti-A and anti-B response
      • Impairs immune system’s ability to discriminate between friend and foe
      • Requires the body to maintain higher Natural Killer (NK) cell activity

Increased Risks

    • Celiac disease
    • Rheumatic heart disease
    • Kidney disease
    • “Leaky gut”
    • Poor defense against parasites
    • Most cancers
    • Chronic viral infections
    • Low-grade infections


    • Secretors
      • Higher risk of low-grade infections than non-secretors
      • Lower NK cell levels than non-secretors
    • Elderly
      • NK cell activity declines to even lower levels with age

If you would like to learn more about how personalized nutrition can work for you and your loved ones, Wellness Made Simple is here to help. We offer individual and group coaching and a wide variety of print materials, online resources, world class products, and lifestyle strategies. It is always the right time to make a fresh start or to uplevel your personal vitality and sense of well-being. Welcome to the #diylife!

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